Neuropathologic Substrate of Mild Cognitive Impairment
نویسندگان
چکیده
منابع مشابه
Neuropathologic substrate of mild cognitive impairment.
OBJECTIVE To define the neuropathologic findings in amnestic mild cognitive impairment (MCI) and early Alzheimer disease (EAD). METHODS The mean numbers of diffuse plaques, neuritic plaques (NPs), and neurofibrillary tangles (NFTs) in 4 neocortical regions and 4 ventromedial temporal lobe regions were counted in 10 patients with amnestic MCI and compared with the mean numbers in 23 normal con...
متن کاملNeuropathologic outcome of mild cognitive impairment following progression to clinical dementia.
BACKGROUND The pathologic outcome of patients diagnosed with mild cognitive impairment (MCI) following progression to dementia is poorly understood. OBJECTIVE To determine the pathologic substrates of dementia in cases with prior diagnosis of amnestic MCI. DESIGN AND SETTING Community-based cohort. PATIENTS Thirty-four subjects followed up prospectively as part of a community-based study ...
متن کاملMild Cognitive Impairment.
PURPOSE OF REVIEW As individuals age, the quality of cognitive function becomes an increasingly important topic. The concept of mild cognitive impairment (MCI) has evolved over the past 2 decades to represent a state of cognitive function between that seen in normal aging and dementia. As such, it is important for health care providers to be aware of the condition and place it in the appropriat...
متن کاملMild Cognitive Impairment
Cognitive aging has positive and negative effects on mental abilities. With time and experience, we gain new knowledge and skills. We become wiser. However, for most adults cognitive aging also brings slower mental processing, reduced mental flexibility, increased susceptibility to distraction, and more difficulty learning new things. As an example, the amount of detail recalled from a short st...
متن کاملMild Cognitive Impairment
It is estimated that up to one third of adults will experience a gradual decline in cognitive function known as mild cognitive impairment as they age (Low LF et al 2004; Busse A et al 2003). Less severe than dementia, mild cognitive impairment is defined as cognitive defects that do not interfere with daily living. It may include slower thinking, a reduced ability to learn, and impaired memory....
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ژورنال
عنوان ژورنال: Archives of Neurology
سال: 2006
ISSN: 0003-9942
DOI: 10.1001/archneur.63.1.38